Plant viruses pose significant threats to agricultural productivity and food security worldwide. Traditional methods of controlling plant viruses, such as chemical treatments and crop rotation, have limitations in efficacy and sustainability. In recent years, RNA-based technologies have emerged as powerful tools for engineering virus-resistant crops. This article explores the revolutionary potential of RNA-based technologies in conferring resistance to plant viruses. We discuss the mechanisms underlying RNA-based immunity, including RNA interference (RNAi) and CRISPR-based approaches, and highlight recent advancements in the development of virus-resistant crops. Additionally, we examine the challenges and opportunities associated with the widespread adoption of RNA-based technologies in agriculture, including regulatory considerations, intellectual property rights, and public acceptance. By harnessing the power of RNA-based technologies, we have the potential to revolutionize plant virus resistance and ensure the resilience of global food systems in the face of emerging viral threats.