The microbial transformation (MIT)of compounds that are raw materials for pharmaceuticals is a valuable aspect of white biotechnology. MIT as its main example cycloperhydrophenanthrene which leads to the synthesis of new and well-known pharmaceuticals. MIT reduces the conversion time of base organic compounds to pharmaceuticals compared to the chemical reactions to synthesize them in the long term, allows savings in time, in investment, with an improvement in the effectiveness and biological activity of the drug: hormones, antibiotics for infectious and genetic diseases such as cancer. Specifically, theMIT of steroids improves the therapeutic potential of drugs, currently even for the prevention of obesity. The objective of this short review is to analyze the status of steroidsby MIT in the pharmaceutical industry. The analysis indicates that MIT is an ancient and today novel strategy that allows white biotechnology to expand treatment options for all types of infectious and non-infectious diseases in harmony with the environment in favor of the quality of human life and with molecular biology the future is promising for long-term public health solutions.