This study examined the perceptions and practices of disease management among farmers in Irasa Farm Cluster, Ado-Ekiti, Nigeria. The findings revealed a notable demographic trend, with the majority of farmers (82.5%) being male, while a smaller proportion (17.5%) were female. Furthermore, the study highlighted a significant educational disparity, with many farmers lacking a tertiary educational background. Despite these challenges, the study found that a significant proportion of farmers (67.5%) employed integrated pest management (IPM) techniques, and 57.5% of the respondents reported using physical methods to control diseases. The study’s findings also highlighted several areas of concern that warrant attention from policymakers, extension agents, and other stakeholders. The reliance on synthetic inputs and the lack of awareness about their long-term impact on soil health are pressing issues that need to be addressed. To address these concerns, the study emphasized the need for increased education and training on sustainable agricultural practices, including disease management, to enhance the resilience and productivity of farming systems in the region. By promoting sustainable agricultural practices and providing targeted support to farmers, it is possible to improve disease management outcomes and contribute to a more sustainable and productive agricultural sector.